Treatment of Neuropathic Pain: Antiepileptic and Antidepressant Drugs - Printer-friendly version
نویسنده
چکیده
Neuropathic Pain Neuropathic pain was originally defi ned by the International Association for the Study of Pain (IASP), in 1994, as “pain initiated or caused by a primary lesion or dysfunction in the nervous system” [57]. In 2008, Treede et al. proposed a redefi nition to “pain arising as a direct consequence of a lesion or disease aff ecting the somatosensory system” [78]. Since then, the IASP has revised the 1994 defi nition to “pain caused by a lesion or disease of the somatosensory nervous system” [36]. Neuropathic pain, which has been reported in 7–10% of the general population in developed countries [79], includes a diverse group of clinical conditions such as cervical or lumbar radiculopathy, diabetic neuropathy, cancer-related neuropathy, postherpetic neuralgia, HIV-related neuropathy, spinal cord injury, multiple sclerosis, central poststroke pain, trigeminal neuralgia, post-traumatic/postsurgical neuropathic pain, and complex regional pain syndrome type II, among others [30]. A very large proportion of clinical drug trials in neuropathic pain have been conducted specifi cally in patients with painful diabetic neuropathy and postherpetic neuralgia [23], leaving other prevalent neuropathic pain conditions such as lumbar radiculopathy relatively understudied with respect to systemic drug treatment [41].
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